1 edition of Guiding nerve fibres in a 3D p(HEMA) Scaffold found in the catalog.
Thesis (M.Sc.) -- University of Toronto, 2003.
|Statement||National Library of Canada|
|Publishers||National Library of Canada|
|The Physical Object|
|Pagination||xvi, 135 p. :|
|Number of Pages||61|
|2||Canadian theses = -- Thèses canadiennes|
nodata File Size: 3MB.
3D printing technology is a convenient method that can be used to fabricate different morphological NGCs that could influence neural cell proliferation and migration. Neural stem cell- and Schwann cell-loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord. The exact mechanisms by which hydrogels interact with SCI also require further study.
Moreover, combining biomaterial scaffolds and cell therapy can promote survival and differentiation of stem cells and reduce the side effect of cell therapy. Bioelectromagnetics 27 4 : 328—31.     142.
These data suggest that aligned collagen fibers are Guiding nerve fibres in a 3D p(HEMA) Scaffold candidates as substrates for guided nerve regeneration.
52 mV at 4 week, 14. Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delay the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury. When the scaffolds were surgically sutured to the proximal and distal stumps of the sciatic nerve, the other tips of the wires was connected to an ES device.
The epineurium is a sheath of loose fibrocollagenous tissue that binds individual fascicles into one nerve trunk. Further studies were needed to identify the optimal parameter of ES which showed best performance in promoting nerve regeneration. He X-X, Zheng J, Yu G-F, et al. Prang et al assessed the capacity of alginate gels to promote directed axonal regrowth in the injured mammalian central nervous system.
Ultrastructure of synapses in the mammalian brain. The results showed this strategy could increase oxygen supply and promote axon regeneration [ ]. The cells can also remodel the electrospun fibers as can be observed in the difference in the mesh density and electrospun fibers visible before and after cell seeding and. B Macroscopic appearance of ACH bodies. Nanofibers that are collected parallel to the direction of the printed fiber are either deposited on top of the printed fiber itself or are aligned within the pore of the previous layer, which in this case is perpendicular to the current layer.
A closer mimicry of the peripheral nerve extracellular matrix ECM is to reconstruct the endoneural tubes within a sheath.
Three important characteristics of scaffolds that promote nerve regeneration include biocompatibility, degradability, and porosity.
The study further showed that muscle satellite cells cultured on LM functionalized pliant hydrogels are able to support extensive muscle regeneration when implanted into immune deficient mice depleted of endogenous satellite cells by irradiation.
Scaffold composition Morphological Properties Mechanical Properties Cell and Tissue Interactions Reference Skeletal Muscle Regeneration PEG functionalized with LM 7.
Hydrogels made from both natural and synthetic materials are anti-inflammatory and alleviate gliosis after SCI, providing a favorable microenvironment for regeneration.
developed a kind of BDNF blended chitosan scaffold to carry umbilical cord mesenchymal stem cells hUC-MSCs through a freeze-dry technique.